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M94A2883.TXT
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1994-10-25
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Document 2883
DOCN M94A2883
TI Anti-HIV flavonoids from Morus alba L.
DT 9412
AU Luo SD; Nemec J; Ning BM; Li QX; Kunming Institute of Botany, China.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):203 (abstract no. PB0240). Unique
Identifier : AIDSLINE ICA10/94369692
AB San Baipi. root of Morus alba L. (Moraceae) is a traditional Chinese
medicine for cough, asthma and other diseases. The alcohol extract of
San Baipi displayed activity against HIV in vitro. Solvent partition,
fractionation on CC and preparing TLC provided three anti-HIV
flavonoids: morusin, kuwanon H and morusin-4'-glucoside. The results of
anti-HIV test of morusin, kuwanon H and their derivatives indicated that
the site between 2-free hydroxy and 3-y,y-dimethylallylic group of these
flavonoids was sensitive to photo-oxidation, and contributed to anti-HIV
activity. This paper is the first report on preparing, physical data,
anti-HIV activity and cytotoxicity of morusin-2'-glucoside,
morusin-4'-glucoside, kuwanon H-6'-aoctare kuwanon H-7-aoetate and
triacetate mulberrofuran D.
DE Alcohol, Ethyl Antiviral Agents/CHEMISTRY/ISOLATION &
PURIF/*PHARMACOLOGY Bioflavonoids/CHEMISTRY/ISOLATION &
PURIF/*PHARMACOLOGY Cells, Cultured/DRUG EFFECTS Drugs, Chinese
Herbal/CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY
Flavones/CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY Human HIV/*DRUG
EFFECTS Photochemistry Plant Extracts MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).